Title:
DESIGNER BONE MORPHOGENETIC PROTEIN
Document Type and Number:
Japanese Patent JP2017029143
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel designer bone morphogenetic protein having a changed affinity for a cognate receptor, a pharmaceutical composition containing the same, and a kit using the composition.SOLUTION: The designer bone morphogenetic protein comprises an amino acid sequence selected from a specific amino acid sequence group. The protein binds to an ALK2 receptor with a Kof about 2 nM or less, binds to an ALK3 receptor with a Kof about 2 nM or less, binds to an ALK6 receptor with Kof about 1 nM or less, binds to an ActRIIA receptor with a Kof about 2 nM or less, binds to an ActRIIB receptor with a Kof about 0.5 nM or less, and binds to a BMPRMA receptor with a Kof about 3.5 nM or less.SELECTED DRAWING: None
Inventors:
STEPHEEN PETER BERASI
CHRISTOPHER TODD BROWN
MCIHAEL JOHN CAIN
VALERIE PERRINE CALABRO
JUO ZONG SEAN
ROBERT VINCENT PAUL MARTINEZ
HOWARD JOEL SEEHERMAN
JOHN MARTIN WOZNEY
CHRISTOPHER TODD BROWN
MCIHAEL JOHN CAIN
VALERIE PERRINE CALABRO
JUO ZONG SEAN
ROBERT VINCENT PAUL MARTINEZ
HOWARD JOEL SEEHERMAN
JOHN MARTIN WOZNEY
Application Number:
JP2016152849A
Publication Date:
February 09, 2017
Filing Date:
August 03, 2016
Export Citation:
Assignee:
WYETH LLC
International Classes:
A61K38/00; C12N15/09; A61L27/00; A61P19/08; C07K14/51; C12P21/02
Domestic Patent References:
| JP2008231125A | 2008-10-02 | |||
| JP2008231125A | 2008-10-02 |
Foreign References:
| WO2009086131A1 | 2009-07-09 | |||
| WO2008051526A2 | 2008-05-02 | |||
| EP1571159A1 | 2005-09-07 | |||
| WO2010030244A1 | 2010-03-18 | |||
| US20060008846A1 | 2006-01-12 | |||
| WO2009086131A1 | 2009-07-09 | |||
| WO2008051526A2 | 2008-05-02 | |||
| EP1571159A1 | 2005-09-07 | |||
| WO2010030244A1 | 2010-03-18 | |||
| US20060008846A1 | 2006-01-12 |
Other References:
"Cytokine & Growth Factor Reviews", 2009, VOL.20, PP.501-507, JPN6015039527
"The EMBO Journal", 2000, VOL.19, NO.13, PP.3314-3324, JPN6017020045
"Cytokine & Growth Factor Reviews", 2009, VOL.20, PP.501-507, JPN6015039527
"The EMBO Journal", 2000, VOL.19, NO.13, PP.3314-3324, JPN6017020045
"The EMBO Journal", 2000, VOL.19, NO.13, PP.3314-3324, JPN6017020045
"Cytokine & Growth Factor Reviews", 2009, VOL.20, PP.501-507, JPN6015039527
"The EMBO Journal", 2000, VOL.19, NO.13, PP.3314-3324, JPN6017020045
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
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