Title:
4,7―ジアルコキシ―N―アセチルノイラミン酸誘導体、および臨床的サンプル中のインフルエンザA型およびB型ウィルスの検出法
Document Type and Number:
Japanese Patent JP4070817
Kind Code:
B2
Abstract:
Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula l groups containing 1 to 4 carbon atoms and R3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3, and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.
Inventors:
Riave, Avraham
Hans Jörgen, Joyce, Anne
Shimasaki, Craig, David
Hans Jörgen, Joyce, Anne
Shimasaki, Craig, David
Application Number:
JP51565598A
Publication Date:
April 02, 2008
Filing Date:
September 05, 1997
Export Citation:
Assignee:
Oklahoma Medical Research Foundation
International Classes:
C07H15/04; C07H7/027; C12Q1/04; C07H15/203; C07H17/02; C07H17/075; C12Q1/34; G01N33/569; C12R1/92
Domestic Patent References:
| JP5505099A |
Foreign References:
| WO1991009971A1 | ||||
| WO1991010744A1 |
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Susumu Kako
Denichi Hashimoto
Kazuo Abe
Susumu Kako
Denichi Hashimoto