Title:
生物活性メチレンブルー誘導体(2)における開発
Document Type and Number:
Japanese Patent JP2007512297
Kind Code:
A
Abstract:
A phenothiazinium compound of Formula (I) for use as an antimicrobial agent for the prevention of microbial infections wherein: Rl, R2, R3 and R4 each independently is an optionally substituted linear, branched or cyclic hydrocarbon group;or Rl and R2 or R3 and R4 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring; X is a counteranion; and P is 1, 2 or 3. The invention also relates to compositions comprising phenothiazinium. compounds, to selected compounds and their use as medicaments, as PDT agents, as photodiagnostic agents, to a conjugate or composite formed between a phenothiazinium. and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated. The compounds are biologically active photosensitisers which are strongly photocytotoxic and have application in the areas of photodynamic therapy (PDT), as well as for the diagnosis and detection of medical conditions and related uses in photochemical internalisation, in the production of cancer vaccines, in the treatment and prevention of microbial infections and in photodisinfection or photosterilisation.
Inventors:
Brown stanley beams
O'Grady Cassandra Claire
Griffith John
Melish Caste Joan
Tunstall Richard George
Roberts David John Howard
Vernon David Ian
O'Grady Cassandra Claire
Griffith John
Melish Caste Joan
Tunstall Richard George
Roberts David John Howard
Vernon David Ian
Application Number:
JP2006540597A
Publication Date:
May 17, 2007
Filing Date:
November 22, 2004
Export Citation:
Assignee:
Photographers Mica Limited
International Classes:
C07D279/18; A01N43/84; A01P3/00; A61K31/5415; C07D401/04; C07D419/04; C09B21/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama