Title:
アミロイドタンパク質を検出するためのデバイス
Document Type and Number:
Japanese Patent JP5863797
Kind Code:
B2
Abstract:
This invention provides a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises for example illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye previously and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
Inventors:
Hultang, Paul Dee.
Barbo, Vincent
Kerberge, charle
Caygle, Gerald Dee.
Niran, Dennis Jay.
Barbo, Vincent
Kerberge, charle
Caygle, Gerald Dee.
Niran, Dennis Jay.
Application Number:
JP2013524895A
Publication Date:
February 17, 2016
Filing Date:
August 12, 2011
Export Citation:
Assignee:
Cognoptics, Incorporated
International Classes:
A61B3/10; A61B3/12; A61B3/13; G01N21/64
Domestic Patent References:
| JP2009264787A | ||||
| JP2011515189A |
Foreign References:
| WO2009120349A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa