膜への膜チャネルの挿入を制御するための装置および方法

Japanese Patent JP6964136

B2

Apparatus and methods for controlling the insertion of a membrane channel into a membrane are disclosed. In one arrangement a first bath holds a first liquid in contact with a first surface of a membrane. A second bath holds a second liquid in contact with a second surface of the membrane. The membrane separates the first and second liquids. A first electrode contacts the first liquid. A second electrode contacts the second liquid. A driving unit applies a potential difference across the membrane via the first and second electrodes to promote insertion of a membrane channel into the membrane from the first liquid or the second liquid. A membrane voltage reduction unit is connected in series with the membrane. The driving unit applies a driving voltage across the membrane voltage reduction unit and the membrane, the driving voltage providing the potential difference across the membrane. The membrane voltage reduction unit is configured such that a reduction in resistance through the membrane caused by insertion of a membrane channel intrinsically increases a potential difference across the membrane voltage reduction unit thereby lowering the potential difference across the membrane. The lowering of the potential difference across the membrane is sufficient to prevent or reduce promotion of insertion of a further membrane channel.

Garalde, Daniel
CLARKE, James
Jenison, mike
Heron, Andrew

JP2019527125A

November 10, 2021

November 24, 2017

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Oxford Nanopole Technologies Limited

G01N27/00; C12M1/34

JP2015051013A
JP7320752A
JP2012026986A
JP2015517799A

WO2016181465A1
WO2016099673A1

Hiroshi Kobayashi
Norio Omori
Go Arai
Yasuhito Suzuki

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