DIACYLHYDRAZINE LIGAND HAVING BIOLOGICAL USABILITY FOR REGULATING EXPRESSION OF EXOGENOUS GENE THROUGH ECDYSONE RECEPTOR COMPLEX

Title:

DIACYLHYDRAZINE LIGAND HAVING BIOLOGICAL USABILITY FOR REGULATING EXPRESSION OF EXOGENOUS GENE THROUGH ECDYSONE RECEPTOR COMPLEX

Document Type and Number:

Japanese Patent JP2014111634

Kind Code:

A

Abstract:

To provide a novel compound for improving ecdysone receptor complex-based gene regulation system.

There is provided a diacylhydrazine ligand compound represented by the following formula, where X and X' are independently O or S, A is an unsubstituted or substituted phenyl and benzo condensed hetero ring, B is unsubstituted or substituted phenyl, unsubstituted 6 membered ring heterocycle or substituted 6 membered ring heterocycle having 1 to 3 nitrogen atoms and 3 to 5 carbon atoms and the like, G is H or CN, E is unsubstituted or substituted alkyl, and the substituted alkyl is substituted by hydroxy, (C1 to C6) alkoxy, (C1 to C6) alkanoyloxy(-COORa), formyl, (C1 to C6) trialkylsilyloxy having the determined number of carbon atoms independently in each alkyl group, -C=N-OH, -C=N-NHC(O)NH2, or -C=N-NHC(O)C(O)NH2 and the like.

More Like This:

WO/2021/089011

COMPOUND WITH BISHYDRAZIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Inventors:

HORMANN ROBERT EUGENE
POTTER DAVID W
CHORTYK ORESTES
TICE COLIN M
CARLSON GLENN RICHARD
MEYER ANDREW
OPIE THOMAS R

Application Number:

JP2014020508A

Publication Date:

June 19, 2014

Filing Date:

February 05, 2014

Export Citation:

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Assignee:

INTREXON CORP

International Classes:

C07C243/38; C07C243/24; C07C251/08; C07C251/38; C07C255/66; C07C281/04; C07C281/10; C07C281/14; C07C309/59; C07C317/44; C07C317/46; C07D209/42; C07D213/81; C07D231/14; C07D235/08; C07D239/28; C07D241/24; C07D319/08; C07F7/18; A61K48/00; C12N

Domestic Patent References:

JP2000037189A	2000-02-08
JPH05163266A	1993-06-29
JPH04243857A	1992-08-31
JPH02108659A	1990-04-20
JPS62167747A	1987-07-24
JPS62175451A	1987-08-01
JPH0881433A	1996-03-26
JPS6323866A	1988-02-01
JPH06298755A	1994-10-25
JP2000026423A	2000-01-25
JPH03141245A	1991-06-17
JP5238159B2	2013-07-17

Foreign References:

GB2231268B	1993-01-27
EP0984009A1	2000-03-08
US4814349A	1989-03-21
US6258603B1	2001-07-10
WO2001060319A2	2001-08-23
DE10324799A1	2004-12-23

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Attorney, Agent or Firm:

Yuichi Yamada
Ikeda adult
Masakazu Noda

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