Title:
Diagnosis and medical treatment of cancer using an anti-ITM2A antibody
Document Type and Number:
Japanese Patent JP6104794
Kind Code:
B2
Abstract:
Disclosed is a monoclonal antibody binding to an ITM2A protein. This antibody is useful in the diagnosis, prevention, and treatment of cancer such as Ewing's sarcoma, T cell leukemia, T cell lymphoma, acute myeloid leukemia, B cell tumor, and multiple myeloma. The present invention also provides a pharmaceutical composition, a cell growth inhibitor, and an anticancer agent containing the antibody as an active ingredient, and a method for treating cancer, a method for predicting the efficacy of cancer treatment, and a method for determining the presence of cancer in a test subject using the antibody.
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Inventors:
Hiroyuki Yutani
Shunpei Ishikawa
Kawai Shigeto
Shunpei Ishikawa
Kawai Shigeto
Application Number:
JP2013510890A
Publication Date:
March 29, 2017
Filing Date:
April 18, 2012
Export Citation:
Assignee:
National University Corporation Tokyo University
Chugai Pharmaceutical Co., Ltd.
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07K16/30; A61K39/395; A61P35/00; A61P35/02; C07K16/46; G01N33/574
Domestic Patent References:
| JP2004187679A |
Foreign References:
| WO2008137500A1 |
Other References:
RIGGI, N. et al.,"EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.",CANCER RES.,2008年 4月 1日,Vol.68, No.7,P.2176-2185
MILLER, B.G. et al.,"Integrative meta-analysis of differential gene expression in acute myeloid leukemia.",PLOS ONE,2010年 3月 1日,Vol.5, No.3,e9466(P.1-13)
STAEGE, M.S. et al.,"DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets.",CANCER RES.,2004年11月15日,Vol.64, No.22,P.8213-8221
KIRCHNER, J. et al.,"ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes.",J. EXP. MED.,1999年 7月19日,Vol.190, No.2,P.217-228
MILLER, B.G. et al.,"Integrative meta-analysis of differential gene expression in acute myeloid leukemia.",PLOS ONE,2010年 3月 1日,Vol.5, No.3,e9466(P.1-13)
STAEGE, M.S. et al.,"DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets.",CANCER RES.,2004年11月15日,Vol.64, No.22,P.8213-8221
KIRCHNER, J. et al.,"ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes.",J. EXP. MED.,1999年 7月19日,Vol.190, No.2,P.217-228
Attorney, Agent or Firm:
Seiji Ohno
Reiko Tanaka
Yuko Matsuniya
Umeda Shinsuke
Reiko Tanaka
Yuko Matsuniya
Umeda Shinsuke
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