Title:
METHOD FOR CANCER DIAGNOSIS, AND DIAGNOSTIC KIT USING NK CELL ACTIVITY
Document Type and Number:
Japanese Patent JP2022043119
Kind Code:
A
Abstract:
To provide a method usable for diagnosis and evaluation of various types of cancer in view of the unceasing need for new methods for this purpose and useful kits and reagents for practicing such methods.SOLUTION: A method and a diagnostic kit for cancer diagnosis together with useful compositions for measuring NK cell activity serve to facilitate monitoring how in vivo immunity systems are changing by way of measuring NK cell activity in blood to determine cancer affection. Therefore, cancer affection can be easily predicted by using blood specimens taken from the suspected patient.SELECTED DRAWING: Figure 6
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Inventors:
LEE JAE MYUN
YOON JOO CHUN
PARK SANG WOO
KIM JONG-SEON
YOON JOO CHUN
PARK SANG WOO
KIM JONG-SEON
Application Number:
JP2021197948A
Publication Date:
March 15, 2022
Filing Date:
December 06, 2021
Export Citation:
Assignee:
NKMAX CO LTD
International Classes:
G01N33/53; C07K14/47; C07K14/54; C07K14/55; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/13; C12N15/24; C12N15/26; C12N15/62; C12N15/63; C12Q1/02
Domestic Patent References:
| JP2005517389A | 2005-06-16 | |||
| JP2010515709A | 2010-05-13 | |||
| JP2007523622A | 2007-08-23 |
Foreign References:
| WO2006110577A2 | 2006-10-19 |
Other References:
CLAUS, M. ET AL.: "Comprehensive analysis of NK cell function in whole blood samples", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 341, JPN6017030198, 3 December 2008 (2008-12-03), pages 154 - 164, ISSN: 0004913065
MENDES, R. ET AL.: "Flow Cytometric Visualisaion of Cytokine Production by CD3-CD56+ NK Cells and CD3+CD56+ NK-T Cells i", CYTOMETRY, vol. 39, JPN6017030201, 2000, pages 72 - 78, ISSN: 0004913066
CLAUS, C. AND WATZL, C.: "Evaluation of Human Natural Killer Cell Activities in Whole Blood", CURRENT PROTOCOLS IN IMMUNOLOGY, vol. 91, no. 1, JPN6020035144, 1 November 2010 (2010-11-01), pages 7 - 39, ISSN: 0004913067
RIBER, U. ET AL.: "Co-incubation with IL-18 potentiates antigen-specific IFN-γ response in a whole-blood stimulation a", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. Vol.139/No.2-4, JPN6020035141, 15 February 2011 (2011-02-15), pages 257 - 63, ISSN: 0004913068
PARIHAR, R. ET AL.: "IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 110, no. 7, JPN6016001759, October 2002 (2002-10-01), pages 983 - 992, XP055148244, ISSN: 0004913069, DOI: 10.1172/JCI15950
CARSON, W.E. ET AL.: "Interleukin (IL) 15 Is a Novel Cytokine That Activates Human Natural Killer Cells via Components of", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, JPN6020035146, October 1994 (1994-10-01), pages 1395 - 1403, XP002244734, ISSN: 0004913070, DOI: 10.1084/jem.180.4.1395
LEE, S.J. ET AL.: "Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Hu", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 1, JPN6016001765, 2001, pages 497 - 504, XP002650662, ISSN: 0004913071
UNO, K. ET AL.: "Differential Interleukin 12 Responsiveness for Interferon γ Production in Advanced Stages of Cancer", CLINICAL CANCER RESEARCH, vol. 4, JPN6020035149, October 1998 (1998-10-01), pages 2425 - 2432, ISSN: 0004913072
MENDES, R. ET AL.: "Flow Cytometric Visualisaion of Cytokine Production by CD3-CD56+ NK Cells and CD3+CD56+ NK-T Cells i", CYTOMETRY, vol. 39, JPN6017030201, 2000, pages 72 - 78, ISSN: 0004913066
CLAUS, C. AND WATZL, C.: "Evaluation of Human Natural Killer Cell Activities in Whole Blood", CURRENT PROTOCOLS IN IMMUNOLOGY, vol. 91, no. 1, JPN6020035144, 1 November 2010 (2010-11-01), pages 7 - 39, ISSN: 0004913067
RIBER, U. ET AL.: "Co-incubation with IL-18 potentiates antigen-specific IFN-γ response in a whole-blood stimulation a", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. Vol.139/No.2-4, JPN6020035141, 15 February 2011 (2011-02-15), pages 257 - 63, ISSN: 0004913068
PARIHAR, R. ET AL.: "IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 110, no. 7, JPN6016001759, October 2002 (2002-10-01), pages 983 - 992, XP055148244, ISSN: 0004913069, DOI: 10.1172/JCI15950
CARSON, W.E. ET AL.: "Interleukin (IL) 15 Is a Novel Cytokine That Activates Human Natural Killer Cells via Components of", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, JPN6020035146, October 1994 (1994-10-01), pages 1395 - 1403, XP002244734, ISSN: 0004913070, DOI: 10.1084/jem.180.4.1395
LEE, S.J. ET AL.: "Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Hu", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 1, JPN6016001765, 2001, pages 497 - 504, XP002650662, ISSN: 0004913071
UNO, K. ET AL.: "Differential Interleukin 12 Responsiveness for Interferon γ Production in Advanced Stages of Cancer", CLINICAL CANCER RESEARCH, vol. 4, JPN6020035149, October 1998 (1998-10-01), pages 2425 - 2432, ISSN: 0004913072
Attorney, Agent or Firm:
Kiyokazu
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