DIAGNOSTIC METHOD OF PANCREATIC CANCER TREATMENT SENSIBILITY AND ENHANCER OF PANCREATIC CANCER TREATMENT SENSIBILITY

Title:

DIAGNOSTIC METHOD OF PANCREATIC CANCER TREATMENT SENSIBILITY AND ENHANCER OF PANCREATIC CANCER TREATMENT SENSIBILITY

Document Type and Number:

Japanese Patent JP2016123340

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a determination method of pancreatic cancer treatment sensibility.SOLUTION: A determination method of pancreatic cancer treatment sensibility comprises (1) measuring at least one kind of miRNA expression level selected from the following miRNAs, in each sample derived from cancerous region or stroma collected from the tumor tissue of human pancreatic cancer; and (2) determining that the pancreatic cancer treatment sensibility of the tumor tissue is low if the measurement value of the sample derived from the stroma obtained in the step (1) is larger as compared with the measurement value of the sample derived from the cancerous region, in all kinds of miRNAs measured in the step (1). hsa-miR-4689; hsa-miR-4664-5p; hsa-miR-4731-5p; hsa-miR-187-5p; hsa-miR-4270; hsa-miR-4697-5p; hsa-miR-4723-5p; hsa-miR-6087; hsa-miR-145-5p; and hsa-miR-125b-5p.SELECTED DRAWING: None

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Inventors:

ISHII HIDESHI
NAGANO HIROAKI
MORI MASAKI
DOKI YUICHIRO
KONNO MASAMITSU
EGUCHI HIDETOSHI
KAWAMOTO KOICHI
NISHIDA HISAHIRO
KOSEKI JUN
HASEGAWA SHINICHIRO
NOGUCHI KOZO
KONDO ISHIZUE
NAKAMURA MAKOTO

Application Number:

JP2014266697A

Publication Date:

July 11, 2016

Filing Date:

December 26, 2014

Export Citation:

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Assignee:

EBANSU:KK
UNIV OSAKA

International Classes:

C12Q1/68; A61K31/7105; A61K35/76; A61K48/00; A61P1/18; A61P35/00; G01N33/50

Domestic Patent References:

JP2009528070A	2009-08-06
JP2010534249A	2010-11-04

Other References:

J. SURG. ONCOL., 2014, VOL. 110, NO. 8, PP. 952-959, JPN6018038840, ISSN: 0004014948
PLOS ONE, 2013, VOL. 8, ISSUE 8, E71978, JPN6018038842, ISSN: 0004014949

Attorney, Agent or Firm:

Patent Business Corporation Saegusa International Patent Office

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