Title:
ジアミンおよびイミノ二酢酸ヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JP2007512367
Kind Code:
A
Abstract:
The present invention relates to a novel class of hydroxamic acid derivatives having a diamine or iminodiacetic acid backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively including terminal differentiation, arresting cell growth and/or apoptosis of neo-plastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compound of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives, and safe, dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
Inventors:
Mirror Thomas A.
Witter David Jay.
Belvedere Sandro
Witter David Jay.
Belvedere Sandro
Application Number:
JP2006541622A
Publication Date:
May 17, 2007
Filing Date:
November 23, 2004
Export Citation:
Assignee:
Aton Pharma Inc.
International Classes:
C07C259/06; A61K31/167; A61K31/18; A61K31/357; A61K31/36; A61K31/4045; A61K31/416; A61K31/4184; A61K31/428; A61K31/4709; A61K31/5377; A61P25/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P39/06; A61P43/00; C07C259/04; C07D209/14; C07D211/16; C07D215/06; C07D215/38; C07D215/40; C07D217/06; C07D231/56; C07D235/30; C07D277/20; C07D277/46; C07D277/82; C07D295/12; C07D317/66; C07D319/18; C07D401/12; A61K
Domestic Patent References:
| JP2005506348A | 2005-03-03 | |||
| JP2003528074A | 2003-09-24 |
Foreign References:
| WO2004113336A1 | 2004-12-29 | |||
| WO2004091518A2 | 2004-10-28 | |||
| WO2002051842A1 | 2002-07-04 | |||
| WO2002014280A1 | 2002-02-21 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi