Title:
ジアミノチアゾール
Document Type and Number:
Japanese Patent JP4173736
Kind Code:
B2
Abstract:
Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.
Inventors:
Chen
Din, kinjie
Gillspie, paul
Kim, Kyunjin
Lobby, Arrangement
Macomas, Warren William
Marin, John Gilfoil Jr.
Perotta, Agostino
Din, kinjie
Gillspie, paul
Kim, Kyunjin
Lobby, Arrangement
Macomas, Warren William
Marin, John Gilfoil Jr.
Perotta, Agostino
Application Number:
JP2002557940A
Publication Date:
October 29, 2008
Filing Date:
January 18, 2002
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D277/20; A61K31/496; A61K31/5377; A61P1/00; A61P11/00; A61P13/08; A61P15/00; A61P35/00; C07C45/63; C07C49/80; C07C49/825; C07C49/84; C07D277/40; C07D277/42; C07D295/073; C07D295/135; C07D295/185; C07D295/205; C07D417/06; C07D417/10; C07D417/12
Domestic Patent References:
| JP2004500304A |
Other References:
SIELECKI, T. M., et al.,Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation,Journal of Medicinal Chemistry,2000年,43(1),pp. 1-18
BARVIAN, M., et al.,Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases,Journal of Medicinal Chemistry,2000年,43,pp. 4606-4616
BARVIAN, M., et al.,Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases,Journal of Medicinal Chemistry,2000年,43,pp. 4606-4616
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama