Title:
DIAMINOTRIAZOLE USEFUL AS INHIBITOR OF PROTEIN KINASE
Document Type and Number:
Japanese Patent JP2011132263
Kind Code:
A
Abstract:
To provide compounds effective as inhibitors of FLT-3, FMS, c-KIT, PDGFR, JAK, AGC subfamily of protein kinase (such as PKA, PDK, p70S6K-1 and -2, and PKB), CDK, GSK, SRC, ROCK and/or SYK protein kinase, and to provide pharmaceutically acceptable compositions thereof.
There are provided protein kinases of formula I. Pharmaceutical compositions containing the compounds, and use methods of the compositions in various diseases are also provided. In specific embodiments, these compounds are effective as inhibitors of FLT-3, JAK-3, PDK-1 and/or SYK protein kinase.
Inventors:
PIERCE ALBERT C
ARNOST MICHAEL
DAVIES ROBERT J
FORSTER CORNELIA J
GALULLO VINCENT
GREY RONALD
LEDEBOER MARK
TIAN SHI-KAI
XU JINWANG
BINCH HALEY
LEDFORD BRIAN
MESSERSMITH DAVID
NANTHAKUMAR SUGANTHI
JAYARAJ ANDREW
WANG JIAN
SALITURO FRANCESCO G
HENKEL GREG
ARNOST MICHAEL
DAVIES ROBERT J
FORSTER CORNELIA J
GALULLO VINCENT
GREY RONALD
LEDEBOER MARK
TIAN SHI-KAI
XU JINWANG
BINCH HALEY
LEDFORD BRIAN
MESSERSMITH DAVID
NANTHAKUMAR SUGANTHI
JAYARAJ ANDREW
WANG JIAN
SALITURO FRANCESCO G
HENKEL GREG
Application Number:
JP2011084103A
Publication Date:
July 07, 2011
Filing Date:
April 05, 2011
Export Citation:
Assignee:
VERTEX PHARMA
International Classes:
C07D249/14; A61K31/4178; A61K31/4196; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4709; A61K31/496; A61K31/501; A61K31/506; A61K31/519; A61K31/53; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K45/00; A61P1/16; A61P3/00; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/00; A61P15/10; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P21/02; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P31/18; A61P31/22; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D249/10; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/10; C07D403/12; C07D403/14; C07D405/04; C07D405/06; C07D405/12; C07D405/14; C07D409/14; C07D413/02; C07D413/12; C07D413/14; C07D417/02; C07D417/04; C07D417/12; C07D417/14; C07D471/14; C07D487/04; C07D495/04
Domestic Patent References:
| JP4783020B2 | 2011-09-28 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita