Title:
Ｐ３８キナーゼ阻害剤としてのジアリール尿素誘導体
Document Type and Number:
Japanese Patent JP6608918
Kind Code:
B2
Abstract:
wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have anti-inflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
Inventors:
Baker, thomas matthew
Fife, Matthew Colin Saw
Jones, Geraint
Tom, Stephen Malcolm
Fife, Matthew Colin Saw
Jones, Geraint
Tom, Stephen Malcolm
Application Number:
JP2017517316A
Publication Date:
November 20, 2019
Filing Date:
October 01, 2015
Export Citation:
Assignee:
Topibert Pharma Limited
International Classes:
C07D213/74; A61K31/44; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/505; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61K31/553; A61K31/675; A61K31/706; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P17/04; A61P17/06; A61P27/02; A61P27/04; A61P27/06; A61P27/14; A61P29/00; A61P37/08; A61P43/00; C07D213/79; C07D213/80; C07D239/47; C07D401/12; C07D413/12; C07D453/02; C07F9/58; C07F9/6512; C07H5/06; C07H15/08
Domestic Patent References:
| JP2007515400A | ||||
| JP2005272474A | ||||
| JP2005527622A | ||||
| JP2002534468A |
Foreign References:
| WO2014027209A1 |
Attorney, Agent or Firm:
Patent corporation ssinpat