Title:
ＣＢ１アロステリック・モジュレーターとしてのジアリール尿素
Document Type and Number:
Japanese Patent JP7455581
Kind Code:
B2
Abstract:
The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.
Inventors:
Yanan Chan
Sai Nguyen
Nadezhda German
Sai Nguyen
Nadezhda German
Application Number:
JP2019555442A
Publication Date:
March 26, 2024
Filing Date:
May 10, 2018
Export Citation:
Assignee:
Research Triangle Institute
International Classes:
C07C275/30
Domestic Patent References:
| JP2008509982A | ||||
| JP2008518014A | ||||
| JP2001526276A | ||||
| JP2003192659A |
Foreign References:
| US6093742 | ||||
| CN104744350A | ||||
| US20110118234 |
Other References:
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CAS REGISTRY NO. 892457-95-3,DATABASE REGISTRY,[online],2006年07月13日,[2022.03.07検索],Retrieved from: STN
CAS REGISTRY NO. 1026041-49-5,DATABASE REGISTRY, [online],2008年06月06日,[2022.10.13検索], Retrieved from: STN
REDDY, L. S. et al.,Crystal Structures of N-Aryl-N'-4-Nitrophenyl Ureas: Molecular Conformation and Weak Interactions Direct the Strong Hydrogen Bond Synthon,Crystal Growth & Design,2007年,Vol. 7,No. 12,pp. 2675-2690
PARK, B. et al.,3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes,Bioorganic & Medicinal Chemistry Letters,2017年01月26日,Vol. 27,No. 5,pp. 1179-1185
CAS REGISTRY NO. 892457-95-3,DATABASE REGISTRY,[online],2006年07月13日,[2022.03.07検索],Retrieved from: STN
CAS REGISTRY NO. 1026041-49-5,DATABASE REGISTRY, [online],2008年06月06日,[2022.10.13検索], Retrieved from: STN
REDDY, L. S. et al.,Crystal Structures of N-Aryl-N'-4-Nitrophenyl Ureas: Molecular Conformation and Weak Interactions Direct the Strong Hydrogen Bond Synthon,Crystal Growth & Design,2007年,Vol. 7,No. 12,pp. 2675-2690
PARK, B. et al.,3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes,Bioorganic & Medicinal Chemistry Letters,2017年01月26日,Vol. 27,No. 5,pp. 1179-1185
Attorney, Agent or Firm:
Kenji Sugimura
Mitsutsugu Sugimura
Mutsuya Yamamoto
Mitsutsugu Sugimura
Mutsuya Yamamoto