Title:
ジアステレオ選択的な還元的アミノ化の方法
Document Type and Number:
Japanese Patent JP4769802
Kind Code:
B2
Abstract:
This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with alpha-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
Inventors:
Chiang, Chi Yeon
Davine, Paul N
Huoster, Bruce S.
Hughes, Gretz
Ossi, Paul
Davine, Paul N
Huoster, Bruce S.
Hughes, Gretz
Ossi, Paul
Application Number:
JP2007524894A
Publication Date:
September 07, 2011
Filing Date:
July 29, 2005
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
AXYS PHARMACEUTICALS, INC.
AXYS PHARMACEUTICALS, INC.
International Classes:
C07C227/04; C07C229/12
Domestic Patent References:
| JP2005526753A | ||||
| JP2003516370A | ||||
| JP51075020A | ||||
| JP1045348A | ||||
| JP62026255A | ||||
| JP5178802A | ||||
| JP2002226457A | ||||
| JP11503727A |
Foreign References:
| US20030232863 | ||||
| US4886813 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura