Title:
DIAZ(EP)INBIS(N-AMIDINOAMIDINE) DERIVATIVE, MANUFACTURE AND ANTIBACTERIAL OR ANTIFUNGAL COMPOSITION
Document Type and Number:
Japanese Patent JPS59225175
Kind Code:
A
Abstract:
A diaz(ep)ine bis(N-amidinoamidine) derivative of the formula:- or a tautomeric form thereof, wherein R<1><0>, R<1><1>, R<1><2>, R<1><3>, R<1><4>, R<1><5>, R<1><6> and R<1><7>, which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 3-18C cycloalkyl or cycloalkylalkyl radical, or an optionally-substituted phenyl (1-4C alkyl) radical, or R<1><0>, R<1><1> and the nitrogen atom to which they are attached, or R<1><2> and R<1><3> and the nitrogen atom to which they are attached, or R<1><4> and R<1><5> and the nitrogen atom to which they are attached, or R<1><6> and R<1><7>, and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical, or R<1><0> and R<1><4> together with the two nitrogen atoms to which they are attached and the intervening carbon atom, or R<1><2> and R<1><6> together with the two nitrogen atoms to which they are attached and the intervening carbon atom, each forms a 1,3-diazaheterocyclic radical of 5 to 7 atoms, which heterocyclic radicals may be the same or different; and m is 2 or 3; provided that R<1><0>, R<1><1>, R<1><2>, R<1><3>, R<1><4>, R<1><5>, R<1><6> and R<1><7> together contain 16 to 28 carbon atoms, and the acid addition salts thereof, processes for their manufacture and antibacterial and antifungal compositions and methods using said compounds.
Inventors:
MAADOTSUKU ARAN AAKIN
DONARUDO MAREI GAN
DENISU PENBAATON
DONARUDO MAREI GAN
DENISU PENBAATON
Application Number:
JP9118384A
Publication Date:
December 18, 1984
Filing Date:
May 09, 1984
Export Citation:
Assignee:
ICI LTD
International Classes:
A01N47/44; A61K8/43; C07D295/20; A61K8/49; A61K31/495; A61P31/04; A61Q11/00; C07D243/04; C07D243/06; C07D295/215; (IPC1-7): C07D295/20; A61K31/495
Attorney, Agent or Firm:
Toshio Yano
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