Dihydroindol useful as potassium channel inhibitor, and a tetrahydroisoquinoline derivative

Japanese Patent JP6100346

B2

A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH2, CH(R5) or C(R5)(R6); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.

Hamlin, Richard, John
Mudge, david
Mura, Mustak
Hart Zourakis, basil
Jones, simon, mark
John, Derek, Edward

JP2015222800A

March 22, 2017

November 13, 2015

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Japan Tobacco Inc.

C07D209/40; A61K31/404; A61K31/4155; A61K31/4178; A61K31/472; A61K31/4725; A61P17/06; A61P25/00; A61P29/00; A61P37/02; A61P43/00; C07D217/22; C07D401/12; C07D401/14; C07D403/12

JP2002511088A
JP2012500836A
JP2012500835A
JP2012500834A
JP2008503594A
JP2007506749A

WO2006077821A1
WO2008038053A1
WO1999042462A1
WO2007109211A1

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma

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