Title:
DIHYDROPYRIDINE ANTIISCHEMIC AND ANTIHYPERTENSIVE
Document Type and Number:
Japanese Patent JPS61167683
Kind Code:
A
Abstract:
1,4-dihydropyridine derivatives of the formula (I): and pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R<1> and R<2> are each independently C1-C4 alkyl or 2-methoxy-ethyl; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; X is a group of the formula: wherein R<3> is H, het, -(CH2)n-het, -NH-het, -NH-(CH2)n-het, -O-het, -O-(CH2)n-het, -(CH2)n-OH, -NR<6>R<7>, -(CH2)nNR<6>R<7> or -NH- -(CH2)pNR<6>R<7>; R<4> is H, C1-C4 alkyl, -(CH2)pNR<6>R<7>, -(CH2)p-OH or -(CH2)n-het; and R<5> is H, C1-C4 alkyl or phenyl; wherein R<6> and R<7> are each independently H or C1-C4 alkyl or the two groups R<6> and R<7> are taken together with the nitrogen atom to which they are attached to form a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(C1-C4 alkyl)piperazinyl group; n is 1-4 and p is 2-4; with the proviso that when R<4> is H or C1-C4 alkyl, R<3> is not H or -NR<6>R<7>. These compounds are useful as anti-ischaemic and anti-hypertensive agents.
Inventors:
DEEBITSUDO ARUKAA
PIITAA EDOWAADO KUROSU
PIITAA EDOWAADO KUROSU
Application Number:
JP982486A
Publication Date:
July 29, 1986
Filing Date:
January 20, 1986
Export Citation:
Assignee:
PFIZER
International Classes:
A61K31/505; A61P9/08; A61P9/10; A61P9/12; C07D211/90; C07D401/12; C07D401/14; (IPC1-7): A61K31/505; C07D211/00; C07D211/90; C07D213/00; C07D233/00; C07D239/00; C07D401/12; C07D401/14
Attorney, Agent or Firm:
Kyozo Yuasa
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