Title:
DIHYDROPYRIDINE, MANUFACTURE AND ANTIHYPERTENSIVE
Document Type and Number:
Japanese Patent JPS61233667
Kind Code:
A
Abstract:
A dihydropyridine of the formula:- wherein R<1> and R<2> each is alkyl or alkoxyalkyl, wherein R<3> is alkyl, wherein benzene ring A bears one or more substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl or bears the substituent =N-O-N= attached to the 2- and 3-positions; wherein Ar is phenyl, naphthul, tetrahydronaphthyl, indanyl or indenyl which is unsubstituted or which bears one or more substituents or Ar is a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulphur, which ring is saturated or unsaturated, and which ring is unsubstituted or bears one or more substituents, wherein p is 0 or 1; wherein q is 1, 2, 3 or 4; wherein X is -O-, -NH-, -NHCO- or -CONH-; and wherein Y is straight-or branched-chain alkylene which may optionally be interrupted by one or two groups selected from oxygen, sulphur, imino substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1,4-piperidinediyl and amido groups; or an acid-addition salt thereof, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess either beta-adrenergic blocking or calcium ion slow channel blocking properties or both such properties, and may be used in the treatment of hypertension.
Inventors:
RODONII BURAIAN HAAGURIIBUSU
BAANAADO JIYOZEFU MAKUROORIN
SUCHIYUAATO DENETSUTO MIRUZU
BAANAADO JIYOZEFU MAKUROORIN
SUCHIYUAATO DENETSUTO MIRUZU
Application Number:
JP2875886A
Publication Date:
October 17, 1986
Filing Date:
February 12, 1986
Export Citation:
Assignee:
ICI PLC
International Classes:
A61K31/4427; A61K31/455; A61P3/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P25/02; C07C41/00; C07C43/164; C07C67/00; C07C69/716; C07D211/90; C07D401/12; C07D413/04; C07D521/00; (IPC1-7): A61K31/455; C07C43/164; C07C69/716; C07D209/00; C07D211/00; C07D211/90; C07D401/12; C07D521/00
Attorney, Agent or Firm:
Toshio Yano