Title:
抗癌剤として有用な6-[(置換)フェニル]トリアゾロピリミジンの二量体および付加物
Document Type and Number:
Japanese Patent JP2009519954
Kind Code:
A
Abstract:
Certain adducts and dinners of 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals, are disclosed. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
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Inventors:
Yangchon Woo
David M Bram
Karl Bayer
David M Bram
Karl Bayer
Application Number:
JP2008545859A
Publication Date:
May 21, 2009
Filing Date:
December 15, 2006
Export Citation:
Assignee:
Wyeth
International Classes:
C07D487/04; A61K31/519; A61P35/00; A61P43/00; C07D519/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita