Title:
2量体小分子アポトーシス増強剤
Document Type and Number:
Japanese Patent JP4674231
Kind Code:
B2
Abstract:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
Inventors:
Harran, Patrick Zee
Wang, Xiao Tong
De Bravander, Jev Kay
Lee, Lynn
Thomas, Lanny Mathieu
Suzuki, Hidetaka
Wang, Xiao Tong
De Bravander, Jev Kay
Lee, Lynn
Thomas, Lanny Mathieu
Suzuki, Hidetaka
Application Number:
JP2007501911A
Publication Date:
April 20, 2011
Filing Date:
March 01, 2005
Export Citation:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07D403/14; A61K31/165; C07D413/14; C07D495/04; A61K31/41; A61K31/4188; A61K31/422; A61P1/04; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P19/04; A61P19/10; A61P25/00; A61P27/16; A61P29/00; A61P35/00; A61P37/08; A61P43/00
Domestic Patent References:
| JP2004531731A |
Attorney, Agent or Firm:
Kawaguchi International Patent Office