NEW MATERIAL:A dimethylaniline derivative of formula I.
USE: Useful as a cell differentiation-inducing examination reagent or carcinogenetic agent. Since the production exhibits a strong cellular differentiation-inducing activity and has low cellular toxicity, the compound can be utilized for the clarification of cell differentiation mechanism and carcinogenesis mechanism as a biochemical reagent. Orally or parenterally administrable.
PREPARATION: p-Dimethylaminobenzaldehyde of formula II is reacted with sodium cyanide and acetic acid in a solvent such as methanol at -5°C to 5°C to prepare a cyanhydrin ethoxyethyl ether of formula III. The compound of formula III is subsequently reacted with p-bromo-p-toluic acid methyl ester of formula IV to prepare a methyl ester of formula V. The compound of formula V is reacted with hydroxylamine in the presence of a base such as sodium hydroxide in a solvent such as methanol at the room temperature to provide the compound of formula I.
TSUDA HIROHISA
OTSUKA HIROMI
MATSUSHITA HAJIME
