Title:
ヒト細胞への遺伝物質の標的化導入のための指向性改変組換えウイルス粒子およびそれらの使用
Document Type and Number:
Japanese Patent JP2020525020
Kind Code:
A
Abstract:
共有結合、例えば、イソペプチド結合を形成して、キャプシドタンパク質上に標的化リガンドを提示する特異的タンパク質：タンパク質結合対を介して、組換えウイルスキャプシド粒子を再配向させるための組成物および方法を本明細書に提供し、この標的化リガンドが、対象細胞上に発現される細胞表面マーカーに特異的に結合する。
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Inventors:
Sabin, rear
Shoenhale, Christopher
Economize, Alice N.
Karatsuos, Christos
Murphy, Andrew Jay.
Shoenhale, Christopher
Economize, Alice N.
Karatsuos, Christos
Murphy, Andrew Jay.
Application Number:
JP2019572025A
Publication Date:
August 27, 2020
Filing Date:
June 27, 2018
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
C12N15/35; A61K35/76; A61K39/395; A61K45/00; A61K47/64; A61K47/65; A61K47/68; A61K48/00; A61P35/00; C07K14/015; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N15/63; C12P21/02
Foreign References:
| WO2016112921A1 | 2016-07-21 |
Other References:
J. VIROL., vol. 76, no. 9, JPN7022003588, 2002, pages 4559 - 4566, ISSN: 0004980121
TRENDS BIOTECHNOL., vol. 32, no. 10, JPN6022031452, 2014, pages 506 - 512, ISSN: 0004980122
PROC. NATL. ACAD. SCI. U.S.A., vol. 113, no. 5, JPN7022003589, pages 1202 - 1207, ISSN: 0004980123
ANGEW. CHEM. INT. ED., vol. 56, JPN6022031454, 2017, pages 16521 - 16525, ISSN: 0004980124
TRENDS BIOTECHNOL., vol. 32, no. 10, JPN6022031452, 2014, pages 506 - 512, ISSN: 0004980122
PROC. NATL. ACAD. SCI. U.S.A., vol. 113, no. 5, JPN7022003589, pages 1202 - 1207, ISSN: 0004980123
ANGEW. CHEM. INT. ED., vol. 56, JPN6022031454, 2017, pages 16521 - 16525, ISSN: 0004980124
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita