Title:
DISCOVERY TECHNIQUE OF LIGAND
Document Type and Number:
Japanese Patent JP2009109515
Kind Code:
A
Abstract:
To discover a ligand using combined technique.
The present invention discloses a new method for discovery of a ligand. The technique relies on a process called "tethering", where a potential ligand is bound covalently to a target or "tethered" to be identified ongoingly. In one embodiment configuration, the present invention provides a target-compound tethering. In one embodiment configuration, the target is selected from a group which consists of enzyme, receptor, transferring factor, ligand for receptor, growth factor, cytokine, immunoglobulin, nucleoprotein, signal transmission component, and allosteric enzyme modulation factor.
Inventors:
ERLANSON DANIEL A
BRAISTED ANDREW A
WELLS JAMES
BRAISTED ANDREW A
WELLS JAMES
Application Number:
JP2009020721A
Publication Date:
May 21, 2009
Filing Date:
January 30, 2009
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC
International Classes:
G01N33/50; G01N33/531; C07C323/39; C07C327/32; C07C335/04; C07D207/46; C07D333/38; C07D333/70; C07D401/04; C07D405/12; C07K14/00; C07K14/435; C12Q1/00; C12Q1/68; C12Q1/70; C40B20/08; C40B30/04; C40B40/04; C40B50/14; G01N33/00; G01N33/15; G01N33/53; C07B61/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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