Title:
DISCRIMINATION METHOD OF PROGNOSTIC RISK AFTER PANCREATIC TUMOR EXTRACTION OPERATION
Document Type and Number:
Japanese Patent JP2019213473
Kind Code:
A
Abstract:
To provide prognostic discrimination methods of pancreatic tumor effective for early diagnosis of pancreatic tumor or definition of malignancy of pancreatic tumor.SOLUTION: Provided is a prognostic discrimination method of pancreatic tumor comprising: a first step of measuring the methylation status of a 5'-side untranslated region or a region including the 5'-side untranslated region and a translated region of a cancer gene and/or a cancer-suppressing gene in a specimen sample derived from a subject; and, in order to discriminate the prognosis of the subject's pancreatic tumor, a second step of substituting a measured value of the methylation status of the 5'-side untranslated region or the region including the 5'-side untranslated region and the translated region of the cancer gene and/or the cancer-suppressing gene obtained in the first step, for the discriminant of a machine learning model using, as a teacher, measurement values obtained by measuring the methylation status of the 5'-side untranslated region or the region including the 5'-side untranslated region and the translated region of the cancer gene and/or the cancer-suppressing gene in a plurality of specimen samples that are known to be a specimen sample derived from tumor tissue or a specimen sample derived from non-tumor tissue.SELECTED DRAWING: None
Inventors:
YOKOYAMA SEIYA
TANIMOTO AKIHIDE
AZUMA MICHIYO
TANIMOTO AKIHIDE
AZUMA MICHIYO
Application Number:
JP2018111885A
Publication Date:
December 19, 2019
Filing Date:
June 12, 2018
Export Citation:
Assignee:
UNIV KAGOSHIMA
International Classes:
C12Q1/6827
Foreign References:
| WO2017062867A1 | 2017-04-13 | |||
| WO2013002422A1 | 2013-01-03 |
Other References:
ONCOTARGET, vol. 7, no. 27, JPN6021047435, 2016, pages 42553 - 42565, ISSN: 0004755327
Attorney, Agent or Firm:
Hiraki International Patent Office