Title:
Disposal of a tight junction and reinforcement of an extracellular matrix which received leakiness or damage
Document Type and Number:
Japanese Patent JP6112621
Kind Code:
B2
Abstract:
Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
Inventors:
Rutridge Ellis-Baink
Stephen Richard Kelly
Terence W. Nooch
Stephen Richard Kelly
Terence W. Nooch
Application Number:
JP2014227726A
Publication Date:
April 12, 2017
Filing Date:
November 10, 2014
Export Citation:
Assignee:
Arch Biosurgery, Inc.
International Classes:
A61K38/00; A61K38/08; A61K45/00; A61P1/00; A61P9/10; A61P9/14; A61P17/02; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P43/00
Foreign References:
| WO2006116524A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office