DNA ENCODING EPITHELIAL CELL SPECIFIC GROWTH FACTOR

Japanese Patent JP3802292

B2

PROBLEM TO BE SOLVED: To obtain a new keratin cell growth factor protein having N-terminal region and C terminal region in number to cause selective mitogen activity on epithelium-derived cell, useful for examining the mitogen activity of test sample on keratin cell, etc.
SOLUTION: This isolated glycosylated or nonglycosylated keratin cell growth factor(KGF) protein is a new KGF protein having N-terminal region containing amino acid 32-64 and C-terminal region containing amino acid 65-156 and 161-189 in number enough to cause selective mitogen activity on an epithelium-derived cell bonded to the protein and is useful for a method for examining mitogen activity of a test sample on a keratin cell. The KGF protein is obtained by constructing a cDNA library by using an RNA extracted from a human fetal pulmonary fibroblast system, screening the library by using a DNA encoding a KGF amino acid sequence as a probe and expressing an obtained gene in an expression system.

Jeffrey S. Rubin
Paul Winch Finch
Stuart A Aaronson

JP28551799A

July 26, 2006

January 30, 1990

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Jeffrey S. Rubin
Paul Winch Finch
Stuart A Aaronson

A61K39/395; C07K14/50; A61K38/00; A61K38/18; A61K38/22; A61P17/02; A61P43/00; C07H21/04; C07K1/16; C07K14/00; C07K14/435; C07K14/47; C07K14/475; C07K14/485; C07K16/00; C07K16/22; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/08; C12N5/10; C12N15/09; C12N15/12; C12N15/18; C12N15/63; C12N15/70; C12N15/79; C12P21/00; C12P21/02; C12Q1/68; C12Q1/6876; G01N33/48; G01N33/50; G01N33/53; C12R1/91; (IPC1-7): C12N15/09; A61K38/22; A61P17/02; A61P43/00; C07K14/47; C07K14/50; C07K19/00; //C12P21/02

EMBO J.,Vol.5,No.5(1986)p.919-924

Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto

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