Title:
DNA METHYL TRANSFERASE INHIBITOR
Document Type and Number:
Japanese Patent JP2008069162
Kind Code:
A
Abstract:
To provide broad-spectrum antibiotics that are inhibitors of bacterial adenine DNA methyltransferases.
A pharmacetical composition comprises a compound of di-(p-fluorophenyl)borinic acid 8-hydroxyquinoline ester, di-(p-chlorophenyl)borinic acid 8-hydroxyquinoline ester, diphenylborinic acid 8-hydroxyquinoline ester, di-(p-fluorophenyl)borinic acid 8-ethanolamine ester, di-(p-chlorophenyl)borinic acid 8-ethanolamine ester, N4-[2-(diphenylboryloxy)ethyl]pyrimidine-4,6-diamine, or N-[2-(diphenylboryloxy)ethyl]-1H-imidasol-4-carboxamidine.
Inventors:
BENKOVIC STEPHEN J
SHAPIRO LUCILLE
BAKER STEPHEN J
WAHNON DAPHNE C
WALL MARK
SHAPIRO LUCILLE
BAKER STEPHEN J
WAHNON DAPHNE C
WALL MARK
Application Number:
JP2007252267A
Publication Date:
March 27, 2008
Filing Date:
September 27, 2007
Export Citation:
Assignee:
PENN STATE RES FOUND
International Classes:
A61K31/69; C12N9/99; A61K31/52; A61K31/7076; A61P31/04; A61P43/00; C07D473/00; C07D473/34; C07F5/02; C07H19/16; C07H19/167; C07H19/173; C07H19/20
Foreign References:
| US3485864A | 1969-12-23 | |||
| US5348948A | 1994-09-20 | |||
| WO2000044387A1 | 2000-08-03 |
Attorney, Agent or Firm:
Hidekazu Miyoshi