Title:
Dosage forms for parenteral for dealing with endometriosis which emit aromatase inhibitor and Gestagen
Document Type and Number:
Japanese Patent JP6012048
Kind Code:
B2
Abstract:
The present invention for the treatment of endometriosis relates to providing a parenteral dosage form (delivery system) for the controlled release of an aromatase inhibitor (AI) in a daily release rate that does not induce stimulation of the ovaries by negative feed-back of the pituitary-ovarian-axis (which would cause secretion of gonadotropins and stimulation of ovarian follicular growth) and a gestagen in a daily release rate below the ovulation inhibition dose that provides contraceptive efficacy based on local effects (e.g. reducing and thickening of the cervical mucus impairing sperm ascension, effects on the endometrium and on tubal motility impairing implantation and egg transport).
Inventors:
Alto packarin
Rodolph Knaute
Heinz Schmitz
Christian Talling
Harri Yukariinen
Henrykka Colorinen
Rodolph Knaute
Heinz Schmitz
Christian Talling
Harri Yukariinen
Henrykka Colorinen
Application Number:
JP2013501792A
Publication Date:
October 25, 2016
Filing Date:
March 28, 2011
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
A61K31/4196; A61K9/00; A61K31/57; A61P15/00; A61P43/00
Domestic Patent References:
| JP2006516602A | ||||
| JP2005501854A |
Foreign References:
| US20050101579 |
Other References:
Steril., 2005, vol.84, No.4, p.1033-1036
日産婦誌, 2007, Vol.59, No.9, p.N471-N475
京府医大誌, 2009, Vol.118, No.1, p.3-12
日産婦誌, 2007, Vol.59, No.9, p.N471-N475
京府医大誌, 2009, Vol.118, No.1, p.3-12
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe
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