Title:
DRUG-LOADED MICROBEAD COMPOSITIONS, EMBOLIZATION COMPOSITIONS, AND ASSOCIATED METHODS
Document Type and Number:
Japanese Patent JP2023099115
Kind Code:
A
Abstract:
To provide microbeads for chemoembolization, methods for preparing the microbeads, and embolization therapy using the microbeads.SOLUTION: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material, and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1 wt.% based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in embolization therapy. Methods for preparing the drug-loaded microbead composition and the embolization composition include loading a therapeutic agent into a water-swellable polymer material to form microbeads, and then removing water from the microbeads.SELECTED DRAWING: None
Inventors:
HIEP DO
MICHAEL RANDALL
MICHAEL RANDALL
Application Number:
JP2023074092A
Publication Date:
July 11, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
BARD INC C R
International Classes:
A61K9/16; A61K31/704; A61K47/02; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K47/46; A61K47/61; A61P35/00
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Kenji Takeda
Toru Miyamae
Junichi Matsuo
Kenji Takeda
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