Title:
薬物放出調節型多層コーティングステント及びその製造方法
Document Type and Number:
Japanese Patent JP4897267
Kind Code:
B2
Abstract:
The present invention provides a multilayer-coated stent for controlled drug release, comprising: a first base layer formed on a stent support and made of poly(ethylene-co-vinylacetate) or polystyrene-ethylene-butylene rubber polymer; a second coating layer formed on the first base layer and made of a biocompatible or a bioabsorbable polymer and a drug component; and a third coating layer formed on the second coating layer and made of a biocompatible or a bioabsorbable polymer and a drug component different from the drug component of the second coating layer. The inventive stent can deliver a broad range of therapeutic substances for a long time and prevent the early rapid release of the drug components in blood. Also, unlike the existing drug-coated stents, the inventive stent includes two kinds of drugs complementary to each other, but can optimize the efficacy of the drugs by differentiating the control of drug release according to time.
Inventors:
Lee Kyung Bum
Park Seung Jung
Lee Chul Fan
Park Seung Jung
Lee Chul Fan
Application Number:
JP2005301528A
Publication Date:
March 14, 2012
Filing Date:
October 17, 2005
Export Citation:
Assignee:
Lee Kyung Bum
International Classes:
A61L17/10; A61F2/82; A61K31/337; A61K31/4709; A61L31/00; A61L31/10; A61L31/16; A61M29/00; A61M29/02; A61P7/02; A61P35/00
Domestic Patent References:
| JP2004089233A | ||||
| JP2003033439A |
Foreign References:
| WO2003082368A1 | ||||
| WO2004000379A1 | ||||
| US20020094440 | ||||
| WO2003099169A1 | ||||
| US6358556 | ||||
| US20020051730 | ||||
| WO2003079936A1 |
Attorney, Agent or Firm:
Shinki Global IP Patent Corporation