Title:
マトリックスメタロプロテアーゼ-9の産生を阻害するための薬剤
Document Type and Number:
Japanese Patent JP4480128
Kind Code:
B2
Abstract:
A drug for inhibiting the production of matrix metalloproteinase-9 which contains leptomycin B or its derivative as the active ingredient can specifically inhibit the production of MMP-9 compared with MMP-2, furthermore, has an effect of inhibiting the production of MMP-9 even under stimulating the differentiation by adding calcium at a high concentration or adding TGF- beta , and under stimulating for inducing inflammation by adding TNF- alpha or adding IL-1 alpha .
Inventors:
Takashi Kobayashi
Application Number:
JP2003286386A
Publication Date:
June 16, 2010
Filing Date:
August 05, 2003
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
A61K31/366; C12N15/09; A61K31/351; A61P9/00; A61P17/00; A61P17/02; A61P17/16; A61P35/00; A61P35/04; A61P43/00; C07D309/32
Domestic Patent References:
| JP61109717A | ||||
| JP62065692A | ||||
| JP5039283A | ||||
| JP63203676A | ||||
| JP60120874A | ||||
| JP8239379A |
Other References:
The Journal of Antibiotics,1983年,Vol.XXXVI, No.6,639-650頁
南山堂 医学大辞典,1990年 2月 1日,17版,218, 1030, 1408, 1499, 1837頁
南山堂 医学大辞典,1990年 2月 1日,17版,218, 1030, 1408, 1499, 1837頁
Attorney, Agent or Firm:
Kenji Akatsuka