Title:
DUAL INHIBITOR OF WAX ESTER AND CHOLESTERYL ESTER SYNTHESIS FOR INHIBITING SEBUM PRODUCTION
Document Type and Number:
Japanese Patent JP2003104878
Kind Code:
A
Abstract:
To provide a method for using a compound that inhibits wax ester synthesis, and cholesteryl ester synthesis, to inhibit sebum production in patients, thereby treating a sebaceous gland disorder by the overproduction of sebum.
A method of inhibiting sebum production and treating sebaceous gland disorders comprises administering to a patient for a treatment an effective amount of the compound that inhibits acyl-coenzyme A: cholesteryl acyltransferase (ACAT) and acyl-coenzyme A: fatty alcohol acyltransferase (AFAT), provided that the compound is [(2,4,6-triisopropyl-phenyl)-acetyl]- sulfamic acid 2,6-diisopropylphenyl ester or a pharmaceutically acceptable salt or solvate thereof.
Inventors:
HOMAN REYNOLD
Application Number:
JP2002222616A
Publication Date:
April 09, 2003
Filing Date:
July 31, 2002
Export Citation:
Assignee:
WARNER LAMBERT CO
International Classes:
A61K31/00; A61K31/17; A61K31/18; A61K31/255; A61K31/27; A61K31/325; A61K31/64; A61P17/00; A61P5/38; A61P17/08; A61P17/10; A61P17/16; A61P43/00; (IPC1-7): A61K31/17; A61K31/255; A61K31/27; A61P5/38; A61P17/08; A61P17/10; A61P17/16; A61P43/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)