DOUBLE-LABELED PROBE FOR MOLECULAR IMAGING AND USE THEREOF

Title:

DOUBLE-LABELED PROBE FOR MOLECULAR IMAGING AND USE THEREOF

Document Type and Number:

Japanese Patent JP2023145464

Kind Code:

A

Abstract:

To provide specific compounds having improved tumor-to-organ ratios.SOLUTION: The present invention provides a compound represented by formula (I): (A)-x1-(B)-x2-(C) or a pharmaceutically acceptable salt thereof (where (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) is at least one chelator moiety of radiometals; (C) is a dye moiety; x1 is a spacer covalently connecting (A) and (B); and x2 is a spacer or a chemical single bond connecting (B) and (C), where (C) is represented by the formula illustrated below).SELECTED DRAWING: None

More Like This:

JP2023521465	Combination therapy of cancer based on ICOS antibody and PD-L1 antibody TGF-β-receptor fusion protein
JP2019500899	Tracking and Manipulating Cellular RNA Through CRISPR / Cas9 Nuclear Delivery
JP2023517403	ACE2 and complement pathway bispecific and trispecific functional molecules and uses thereof

Inventors:

ANN-CHRISTIN EDER
MATTHIAS EDER
KLAUS KOPKA
MARTIN SCHAEFER
ULRIKE BAUDER-WUEST
UWE HABERKORN

Application Number:

JP2023110649A

Publication Date:

October 11, 2023

Filing Date:

July 05, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

DEUTSCHES KREBSFORSCH
UNIV HEIDELBERG RUPRECHT KARLS

International Classes:

A61K47/64; A61K49/00; A61K51/08; A61P35/00; C07K7/06

Attorney, Agent or Firm:

Patent Attorney Corporation Hiraki International Patent Office

Previous Patent: Radiation-sensitive resin composition and resist pattern formation method

Next Patent: Mist screen connector and mist screen forming device