Title:
眼圧降下剤としてのEP▲下2▼受容体作動剤
Document Type and Number:
Japanese Patent JP4275194
Kind Code:
B2
Abstract:
The invention relates to (+/-) trans-2-[-4(1-hydroxyhexyl) phenyl]-5-oxocyclopentaneheptanoic acid, and ester and unsaturated derivatives thereof, prostaglandin derivatives. More particularly, the present invention concerns compounds of the formula I alpha or beta configuration, the dashed bond represents either a single or double bond, which double bond may be a cis or trans double bond and R is a saturated or unsaturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or -(CH2)mR1 wherein m is 0-10, and R1 is an aliphatic ring having from about 3 to about 7 carbon atoms, or an aryl or heteroaryl ring having from about 4 to about 10 carbon atoms and wherein the heteroatom is selected from the group consisting of N, O and S. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
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Inventors:
Woodward, David F
Application Number:
JP51958195A
Publication Date:
June 10, 2009
Filing Date:
January 09, 1995
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
A61K31/557; A61K45/00; A61K31/5575; A61P27/02; A61P27/06; A61P43/00; C07C405/00
Other References:
Gardiovascular Drug Reviews, 1993年, Vol.11,No.2,p.165-179
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda
Kenji Asai
Fumiaki Otsuka
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda
Kenji Asai