Title:
ミトコンドリアＤＮＡの編集
Document Type and Number:
Japanese Patent JP2018524992
Kind Code:
A
Abstract:
ミトコンドリアDNA内に標的変化(例えば、欠失)を作製するための材料および方法が記載されている。【選択図】なし
Inventors:
Ecker, Stephen Sea.
Campbell, Jarry M.
Campbell, Jarry M.
Application Number:
JP2018503580A
Publication Date:
September 06, 2018
Filing Date:
July 22, 2016
Export Citation:
Assignee:
Mayo Foundation for Medical Education and Research
International Classes:
C12N15/09; C07K19/00; C12N1/15; C12N1/19; C12N5/10; C12N9/04; C12N9/16; C12N15/62; C12N15/67; C12N15/87
Domestic Patent References:
| JP2013513389A | 2013-04-22 | |||
| JP2003061694A | 2003-03-04 |
Foreign References:
| WO2014144987A2 | 2014-09-18 | |||
| WO2013191769A1 | 2013-12-27 |
Other References:
BACMAN, SR, ET AL: "Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs", NAT MED, vol. 19(9), JPN6020033493, 2013, pages 1111 - 1113, ISSN: 0004588717
REDDY, P., ET AL: "Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing", CELL, vol. 161, JPN6020033497, 23 April 2015 (2015-04-23), pages 459 - 469, XP055414794, ISSN: 0004588718, DOI: 10.1016/j.cell.2015.03.051
GAMMAGE, PA, ET AL: "Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing", EMBO MOLECULAR MEDICINE, vol. 6（４）, JPN6020033500, 2014, pages 458 - 466, ISSN: 0004588719
BITINAITE, J., ET AL: "FokI dimerization is required for DNA cleavage", PNAS, vol. 95, JPN6020033504, 1998, pages 10570 - 10575, XP002212149, ISSN: 0004341210, DOI: 10.1073/pnas.95.18.10570
REITMAN, ZJ, ET AL: "Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabo", J NATL CANCER INST., vol. 102（13）, JPN6020033507, 2010, pages 932 - 941, ISSN: 0004588721
KIL, IS, ET AL.: "Small interfering RNA-mediated silencing of mitochondorial NADP+-dependent isocitrate dehydrogenase", FREE RADIC BIOL MED., vol. Vol.43, No.8, p.1197-1207, JPN6020033510, 20 July 2007 (2007-07-20), ISSN: 0004588722
REDDY, P., ET AL: "Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing", CELL, vol. 161, JPN6020033497, 23 April 2015 (2015-04-23), pages 459 - 469, XP055414794, ISSN: 0004588718, DOI: 10.1016/j.cell.2015.03.051
GAMMAGE, PA, ET AL: "Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing", EMBO MOLECULAR MEDICINE, vol. 6（４）, JPN6020033500, 2014, pages 458 - 466, ISSN: 0004588719
BITINAITE, J., ET AL: "FokI dimerization is required for DNA cleavage", PNAS, vol. 95, JPN6020033504, 1998, pages 10570 - 10575, XP002212149, ISSN: 0004341210, DOI: 10.1073/pnas.95.18.10570
REITMAN, ZJ, ET AL: "Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabo", J NATL CANCER INST., vol. 102（13）, JPN6020033507, 2010, pages 932 - 941, ISSN: 0004588721
KIL, IS, ET AL.: "Small interfering RNA-mediated silencing of mitochondorial NADP+-dependent isocitrate dehydrogenase", FREE RADIC BIOL MED., vol. Vol.43, No.8, p.1197-1207, JPN6020033510, 20 July 2007 (2007-07-20), ISSN: 0004588722
Attorney, Agent or Firm:
Hiraki International Patent Office