Title:
Efficient synthesis of ethylene dicysteine-sugar conjugates for imaging and treatment
Document Type and Number:
Japanese Patent JP6336695
Kind Code:
B2
Abstract:
Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
Inventors:
Yang, David Jay.
You, Don-Fan
You, Don-Fan
Application Number:
JP2015503472A
Publication Date:
June 06, 2018
Filing Date:
March 26, 2013
Export Citation:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07H5/06
Domestic Patent References:
| JP2010505858A | ||||
| JP2003534388A | ||||
| JP2006515835A | ||||
| JP2008531755A | ||||
| JP4505152A |
Other References:
P. Blondeau et al.,Dimerization of an intermediate during the sodium in liquid ammonia reduction of l-thiazolidine-4-carboxylic acid,Canadian Journal of Chemistry,1967年,45(1),pp. 49-52
Yang Yanb et al.,Antioxidative properties of a newly synthesized 2-glucosamine-thiazolidine-4(R)-carboxylic acid (GlcNH2Cys) in mice,Nutrition Research,2006年,26(7),pp. 369-377
Yang Yanb et al.,Antioxidative properties of a newly synthesized 2-glucosamine-thiazolidine-4(R)-carboxylic acid (GlcNH2Cys) in mice,Nutrition Research,2006年,26(7),pp. 369-377
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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