Title:
プロテインチロシンキナーゼ阻害薬中間体の調製のためのエナンチオ選択性生体内変換
Document Type and Number:
Japanese Patent JP2008510791
Kind Code:
A
Abstract:
The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.
Inventors:
Kun, Pay-Pay
Martinez, Carlos Alberto
Tao, Chunhwa
Martinez, Carlos Alberto
Tao, Chunhwa
Application Number:
JP2007529037A
Publication Date:
April 10, 2008
Filing Date:
August 15, 2005
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07C33/46; C07C27/02; C07C29/09; C12P7/22; C07B53/00; C07D213/73
Attorney, Agent or Firm:
Yoshinobu Murofushi