To enantioselectively obtain the subject high-purity compound useful as a systemic germicide in high optical purity simply by selecting aldehydes having the p-position of an aromatic ring masked with t-butyl as a starting substance and reducing the selected aldehydes.
2-Methyl-(4'-t-butyl)cinnamaldehyde of formula I is used as a starting substance and reduced to provide S-3-(4'-t-butyl)-phenylpropanol of formula II, which is then halogenated with a suitable halogenating agent such as thionyl chloride without causing the racemization to afford a compound of formula III (A is a halogen). The resultant compound of formula III is finally alkylated with a secondary amine such as piperidine and cis-3,5-dimethyl- phosphine to provide S-3-(4'-t-butyl)-phenyl-2-methyl-propylamine of formula IV (NR1R2 is a dialkylamine, pyrrolidine, piperidine, cis-3,5-dimethyl-morpholine).
JPS6033808 | [Title of the Invention] Full Orode hydroxylation of alcohol |
JP2000256230 | NOVEL METHOD FOR PRODUCING CYCLOPROPYLMETHYL IODIDE |
JPS58210032 | POLYPRENYL COMPOUND |
MAJERIC MAJA (HR)
HAMERSAK ZDENKO (HR)
AVDAGIC AMIR (HR)
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