Title:
ENGINEERED POLYPEPTIDES
Document Type and Number:
Japanese Patent JP2023058568
Kind Code:
A
Abstract:
To provide engineered polypeptides.SOLUTION: Provided herein are polypeptides that bind to a blood-brain barrier (BBB) receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a BBB receptor-expressing cell, e.g., for transport across the BBB. Also provided herein are transferrin receptor (TfR) constructs that comprise a monomeric TfR apical domain or one or more portions of the TfR apical domain which have been circularly permuted relative to the full-length TfR sequence.SELECTED DRAWING: None
Inventors:
Chen Xiao Chen
Cariolis Mihalis
Wells Robert Sea.
Cariolis Mihalis
Wells Robert Sea.
Application Number:
JP2023016182A
Publication Date:
April 25, 2023
Filing Date:
February 06, 2023
Export Citation:
Assignee:
Denali Therapeutics Inc.
International Classes:
C12N15/12; C07K1/14; C07K14/705; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12N15/63; C12N15/67; C12P21/02; G01N33/53; G01N33/543
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Previous Patent: JPWO2023058567
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