Title:
操作された標的特異的なヌクレアーゼ
Document Type and Number:
Japanese Patent JP7275152
Kind Code:
B2
Abstract:
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
Inventors:
Dickerber, Russell
Crivega, Ivan
Miller, Jeffrey Sea.
Jean, Rey
Crivega, Ivan
Miller, Jeffrey Sea.
Jean, Rey
Application Number:
JP2020542727A
Publication Date:
May 17, 2023
Filing Date:
February 08, 2019
Export Citation:
Assignee:
Sangamo Therapeutics, Incorporated
International Classes:
C12N15/55; A61K35/76; A61K38/46; A61K38/47; A61K48/00; A61P3/00; A61P7/04; A61P43/00; C12N9/16; C12N15/09; C12N15/12; C12N15/56; C12N15/62; C12N15/864
Domestic Patent References:
| JP2017504354A |
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto