Title:
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
Document Type and Number:
Japanese Patent JP6420273
Kind Code:
B2
Abstract:
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.
Inventors:
Feng Jiang
Les Con
Patrick Shu
Faye Run
Les Con
Patrick Shu
Faye Run
Application Number:
JP2016067687A
Publication Date:
November 07, 2018
Filing Date:
March 30, 2016
Export Citation:
Assignee:
The Broad Institute Incorporated
Massachusetts Institute of Technology
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
Massachusetts Institute of Technology
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
International Classes:
C12N15/09; A01H1/00; A01K67/027
Foreign References:
| WO2014089290A1 | ||||
| WO2014065596A1 |
Other References:
Science, Aug 2012, Vol.337, p.816-821, Supplementary Materials
ZEBRAFISH, 2011, Vol.8, p.147-149
Nucleic Acids Research, 2011, Vol.39, e82
PNAS, 2011, Vol.108, p.2623-2628
Methods, 2011, Vol.53, p.339-346
Annals of Neurosciences, 2011, Vol.18, p.25-28
Nucleic Acids Research, 2011, Vol.40, p.3443-3455
Science, 2003, Vol.300, p.763
BioResearch Open Access, Jun. 2012, Vol.1, p.99-108
Nature Methods, Aug. 2012, Vol.9, p.805-809
Biochimica et Biophysica Acta, 2006, Vol.1758, p.355-363
The Journal of Cell Biology, 1988, Vol.107, p.1279-1287
PNAS, 2011, Vol.108, p.E351-E358
Science, Jan 2013, Vol.339, p.823-826
eLife, Jan 2013, Vol.2, e00471
Nature Biotechnology, Jan 2013, Vol.31, p.227-229
Nature Biotechnology, Jan 2013, Vol.31, p.230-232
ZEBRAFISH, 2011, Vol.8, p.147-149
Nucleic Acids Research, 2011, Vol.39, e82
PNAS, 2011, Vol.108, p.2623-2628
Methods, 2011, Vol.53, p.339-346
Annals of Neurosciences, 2011, Vol.18, p.25-28
Nucleic Acids Research, 2011, Vol.40, p.3443-3455
Science, 2003, Vol.300, p.763
BioResearch Open Access, Jun. 2012, Vol.1, p.99-108
Nature Methods, Aug. 2012, Vol.9, p.805-809
Biochimica et Biophysica Acta, 2006, Vol.1758, p.355-363
The Journal of Cell Biology, 1988, Vol.107, p.1279-1287
PNAS, 2011, Vol.108, p.E351-E358
Science, Jan 2013, Vol.339, p.823-826
eLife, Jan 2013, Vol.2, e00471
Nature Biotechnology, Jan 2013, Vol.31, p.227-229
Nature Biotechnology, Jan 2013, Vol.31, p.230-232
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe
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