ENHANCEMENT OF B CELL ACTIVATION AND IMMUNOGLOBULIN SECRETION BY CO-STIMULATION OF RECEPTORS FOR ANTIGEN AND EBV GP350/220

Japanese Patent JP2012214477

A

To provide vaccine adjuvants comprising the Epstein Barr Virus glycoprotein 350/220 or naturally occurring variants thereof, a fusion protein comprising EBV Gp350/220 sequence which binds to the CR2 receptor, or a synthetically-derived fragment of Gp350/220, and immunostimulatory compositions comprising an EBV Gp350/220 adjuvant sequence that binds the CR2 complex and at least one antigen of interest other than Gp350/220.

Co-administration of the adjuvant with an antigen of interest, other than an antigen comprising EBV 350/220 sequence, enhances the immunogenicitiy of the antigen. The adjuvant is directly or indirectly covalently bound to an antigen of interest to form an immunogenic composition. In a most preferred embodiment of the composition, antibodies are elicited against at least two Gp350/220 epitopes and against at least one epitope of the antigen.

MOND JAMES J
LEES ANDREW

JP2012116568A

November 08, 2012

May 22, 2012

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HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC
MOND JAMES J
LEES ANDREW

A61K39/00; C12N15/09; A61K39/245; A61K39/385; A61K39/39; A61K47/36; A61K47/42; A61K47/48; A61K48/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P37/04; C07K14/05; C07K19/00; C12N15/38; C12R1/93

JP5138844B2

2013-02-06

WO1996017625A1	1996-06-13
WO1990004176A1	1990-04-19
WO1996029094A1	1996-09-26

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

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