Title:
アリールおよびチオで置換された酸の酵素による分割
Document Type and Number:
Japanese Patent JP2004530405
Kind Code:
A
Abstract:
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or -S-R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).
Inventors:
Jin Yang Ju
Li You
Brenda Jay White
Shannon x jao
Paul M. Sconezny
Li You
Brenda Jay White
Shannon x jao
Paul M. Sconezny
Application Number:
JP2002527291A
Publication Date:
October 07, 2004
Filing Date:
September 12, 2001
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07B55/00; C07C67/343; C07C327/08; C12P7/40; C12P7/62; C12P11/00; C12P41/00; C12R1/785; (IPC1-7): C12P41/00; C07B55/00; C07C327/08
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Kyousei Tamura
Toshio Ueda
Osamu Kawamiya
Kyousei Tamura
Toshio Ueda