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Title:
４’−エチルヌクレオシド類似体の酵素的合成
Document Type and Number:
Japanese Patent JP2021530479
Kind Code:
A
Abstract:
本発明は、中間体上の保護基の使用を排除し、グリコシル化の立体選択性を改善し、化合物を製造するのに必要なプロセス段階の数を減少させる、４’−エチニル２’−デオキシヌクレオシドおよびその類似体、例えばＥＦｄＡの酵素的合成に関する。また、当該プロセスで使用される新規中間体に関する。

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Inventors:
Huffman, Mark A
Friskovska, Anna
Korev, Joshua N
Divine, Paul N
Campos, Kevin Earl
Trouppo, Matthew
Nowrat, Christopher Sea
Application Number:
JP2021500463A
Publication Date:
November 11, 2021
Filing Date:
July 02, 2019
Export Citation:
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Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07H19/173; C07C29/88; C07C33/042; C07F9/09; C07F9/655; C07H11/04; C12N9/04; C12N9/12; C12P19/38; C12P19/40
Domestic Patent References:
JP2002095494A2002-04-02
JP2010031103A2010-02-12
Other References:
BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 76, JPN7022001906, 2012, pages 1219 - 1225, ISSN: 0005001168
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 67, JPN6022015596, 2002, pages 1480 - 1489, ISSN: 0005001169
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Takashi Kono
Yoshikazu Iwase
Yasufumi Shiroyama



 
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