Title:
ENZYME-INHIBITING AMINO ACID DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPH02204475
Kind Code:
A
Abstract:
NEW MATERIAL: A compd. represented by formula I [wherein R1 is H, a 1-18C alkyl, 3-7C cycloalkyl, 1-4C alkoxy or 6-14C aryl, A is S, SO, SO2 or O, D is CH2 or NR7 is H or an alkyl), R3 is a 6-14C aryl or 6-14C aryl-1-4C alkyl, B is a phenylalanine wherein an N-terminal is linked to R1-A-D-CHR3-CO by NR8 (R8 is H or a alkyl) and a C-terminal is linked to a group represented by formula II by CO, R2 is H, a 1-10C alkyl or 4-7C cycloalkyl and R4 is a 1-8C alkyl, 3-8C cycloalkyl or 3-8C alkyl] or its salt.
USE: Useful for treating hypertension or virus diseases.
PROCESS: A compd. represented by formula III is reacted with a hydroxylamine deriv. represented by formula IV to obtain the compd. represented by formula I.
Inventors:
BUORUFUGANGU RIYUUGAA
HANSUIERUKU URUBATSUHA
DEIITAA RUPERUTO
BERUNBUARUTO SHIERUKENSU
HANSUIERUKU URUBATSUHA
DEIITAA RUPERUTO
BERUNBUARUTO SHIERUKENSU
Application Number:
JP32160289A
Publication Date:
August 14, 1990
Filing Date:
December 13, 1989
Export Citation:
Assignee:
HOECHST AG
International Classes:
A61K31/33; A61K31/415; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K38/55; A61P9/12; A61K31/16; A61P31/12; A61P43/00; C07C291/02; C07D213/81; C07D233/64; C07D295/18; C07D333/24; C07D521/00; C07K1/113; C07K5/02; C07K5/06; C07K5/065; C07K14/81; A61K38/00; (IPC1-7): A61K31/16; A61K31/33; A61K31/415; A61K31/44; A61K37/64; C07D213/81; C07D233/64; C07D295/18; C07D333/24; C07D521/00; C07K5/06
Attorney, Agent or Firm:
Chika Takagi (2 outside)
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