Title:
化学及び生物兵器の広域特異性除染のための酵素及び処方物
Document Type and Number:
Japanese Patent JP2009517002
Kind Code:
A
Abstract:
The invention provides novel enzymes and methods for enzyme-based active decontamination, e.g., nerve agent detoxification. In one aspect, the invention provides enzymes having non-heme chloroperoxidase (nhCPOs) activity, and methods for bleaching and degradation of lignin. The invention provides polypeptides, nucleic acids, infective vehicles, transduced or infected cells or plants and/or transgenic plants to, and methods of using them, e.g., provide self-protecting, pesticide-resistant and/or herbicide-resistant cells or plants, where in one aspect the polypeptides of the invention act to hydrolyzing P-S or P-F bonds and detoxify acetylcholinesterases or butyrylcholinesterases. In one aspect, the invention provides an enzyme mixture or composition that provides broad-spectrum, agent-specific oxidation and hydrolysis activities as well as hypohalite generation for oxidation or hydrolysis of V-agents, G-agents and H-agents and which generates oxidants such as chlorine dioxide and reactive radicals for killing of biological agents, including anthrax spores.
Inventors:
Robertson Dan Yi
Richardson Toby
Custejo Karen
Amitai Gabriel
Le June Keith
Barbaric Jason
Chaplin Jennifer Anne
Sinclair Jessica
Richardson Toby
Custejo Karen
Amitai Gabriel
Le June Keith
Barbaric Jason
Chaplin Jennifer Anne
Sinclair Jessica
Application Number:
JP2008535508A
Publication Date:
April 30, 2009
Filing Date:
April 06, 2006
Export Citation:
Assignee:
Verenium Corporation
Agenties Limited Liability Company
Life Sciences Research Israel Limited
Agenties Limited Liability Company
Life Sciences Research Israel Limited
International Classes:
C12N15/09; A01H5/00; A01K67/027; A23L1/305; A61K9/02; A61K9/06; A61K9/08; A61K9/10; A61K9/12; A61K9/127; A61K9/14; A61K9/19; A61K9/20; A61K9/48; A61K33/20; A61K38/00; A61K38/43; A61K38/44; A61K48/00; A61P31/02; A61P39/02; C07K14/00; C07K16/00; C07K16/40; C07K17/00; C07K19/00; C09K23/30; C12M1/00; C12M1/34; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N9/14; C12N9/98; C12P21/02; C12Q1/02; C12Q1/26; C12Q1/34; C12Q1/68; C40B40/08; G01N33/53
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama