Title:
エーテル脂質シグナル伝達経路を制御する酵素
Document Type and Number:
Japanese Patent JP2010505868
Kind Code:
A
Abstract:
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.
Inventors:
Cravat Benjamin F.
Chung Kyle Pee.
Niessen Sherry
Saga Terian Alan
Chung Kyle Pee.
Niessen Sherry
Saga Terian Alan
Application Number:
JP2009531564A
Publication Date:
February 25, 2010
Filing Date:
October 02, 2007
Export Citation:
Assignee:
The Scripts Research Institute
International Classes:
A61K45/00; A61K31/121; A61K31/27; A61K31/7088; A61K45/06; A61K48/00; A61P1/18; A61P15/00; A61P17/00; A61P35/00; A61P43/00; C12Q1/02; C12N15/09
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki