Title:
EPISOMAL REPROGRAMMING WITH CHEMICALS
Document Type and Number:
Japanese Patent JP2016041081
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide episomal reprogramming with chemicals.SOLUTION: Methods and compositions for inducing pluripotent stem cells are disclosed. For example, in certain aspects, methods for generating essentially vector-free, induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.SELECTED DRAWING: None
Inventors:
JUNYING YU
Application Number:
JP2015256084A
Publication Date:
March 31, 2016
Filing Date:
December 28, 2015
Export Citation:
Assignee:
CELLULAR DYNAMICS INTERNAT INC
International Classes:
C12N5/10; A61K35/545
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto