Title:
エポチロン誘導体
Document Type and Number:
Japanese Patent JP4885067
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formulaQ is selected from the group consisting ofG is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo,W is O or NR15;X is O or H,H;Y is selected from the group consisting of O; H,OR16; OR17,OR17; NOR18; H,NOR19; H,NR20R21; H,H; or CHR22; OR17 OR17 can be a cyclic ketal;Z1, and Z2 are selected from the group consisting of CH2, O, NR23, S, or SO2, wherein only one of Z and Z2 is a heteroatom;B1 and B2 are selected from the group consisting of OR24, or OCOR25, or O2CNR26R27; when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal;D is selected from the group consisting of NR28R29, NR30COR31 or saturated heterocycleR1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, and R27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R1 and R2 are alkyl can be joined to form a cycloalkyl; R3 and R4 are alkyl can be joined to form a cycloalkyl;R9, R10, R16, R17, R24, R25, and R31 are selected from the group H, alkyl, or substituted alkyl;R8, R11, R12, R28, R30, R32, R33, and R30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo;R15, R23 and R29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R32C=O, R33SO2, hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds whereinW and X are both O; andR1, R2, R7, are H; andR3, R4, R6, are methyl; andR8, is H or methyl; andZ1, and Z2, are CH2; andG is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; andQ is as defined above are excluded.
Inventors:
Gregory De Bite
Robert M Borgileri
Soon-Hoon Kim
James A Johnson
Robert M Borgileri
Soon-Hoon Kim
James A Johnson
Application Number:
JP2007156260A
Publication Date:
February 29, 2012
Filing Date:
June 13, 2007
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D313/00; A61K31/335; C07D491/044; A61K31/395; A61K31/427; A61P19/00; A61P35/00; A61P43/00; C07D225/00; C07D273/00; C07D277/26; C07D417/06; C07D417/08; C07D491/04; C07D493/04; C07D498/04
Domestic Patent References:
| JP4090514B2 |
Foreign References:
| WO1997019086A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa
Minato Saito
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa
Minato Saito